Sunday, February 21, 2010
About Intrathecal Baclofen Pump
ITB Therapy (Intrathecal Baclofen Therapy) for the management of severe spasticity uses an implantable infusion system to deliver precise amounts of Lioresal® Intrathecal (baclofen injection) directly to the intrathecal space via a surgically implanted pump and catheter.
The precise mechanism of action of baclofen as a muscle relaxant and antispasticity agent is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level, possibly by decreasing excitatory neurotransmitter release from primary afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Baclofen is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and may exert its effects by stimulation of the GABAB receptor subtype.
Lioresal Intrathecal, when introduced directly into the intrathecal space, permits effective CSF concentrations to be achieved with resultant plasma concentrations 100 times less than those occurring with oral administration.
The precise mechanism of action of baclofen as a muscle relaxant and antispasticity agent is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level, possibly by decreasing excitatory neurotransmitter release from primary afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Baclofen is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and may exert its effects by stimulation of the GABAB receptor subtype.
Lioresal Intrathecal, when introduced directly into the intrathecal space, permits effective CSF concentrations to be achieved with resultant plasma concentrations 100 times less than those occurring with oral administration.
Subscribe to:
Posts (Atom)